Although BEZ235 inhibits both PI3K and mTOR, in combination with RAD001, it exerts synergistic effects in inhibiting the growth of a panel of NSCLC cells as demonstrated in a 3-day monolayer culture (with the SRB assay) and in a long-term 12 days colony formation assay (Figs. 2 and 3). The gene discussed is MTOR; the disease is non-small cell lung carcinoma.