MYH14 and Sepsis: In single muscle fibres separated according to MyHC isoform expression (types I, IIa and IIx), the maximum unloaded shortening velocity (V0) did not change over the five-day period in any of the groups, arguing against a modification of myosin cross-bridge cycling kinetics underlying the decreased specific force in animals exposed to systemic CS administration or sepsis or both (Figure 2).