However, when mice were challenged with a high inoculum of bacteria (2.5×104 IFU per mouse), TLR2-deficient mice did show more exaggerated body weight loss over time compared to control C57BL/6 mice, particularly during the latter half of the course of infection, between days 5–9, suggesting more severe disease (Fig. 2A). This evidence concerns the gene TLR2 and infection.