However, ultrastructural patterns suggesting transition, through progressive loss of particles and proteasome immunoreactivity, from PaCS to amorphous-filamentous structures of the type identified by Bjorkoy et al. [15] as p62-positive sequestosomes destined to autophagy, have been observed in some neoplastic cells, either in vivo from tumour samples (this study) or in cultured cell lines [1]. The gene discussed is SQSTM1; the disease is neoplasm.