PaCSs clearly differ ultrastructurally and cytochemically from a number of cytoplasmic inclusion bodies, including hepatocellular hyaline or Mallory bodies, inclusions of various neurodegenerative diseases and other sequestosomes or aggresomes [11]–[13], which may share with PaCS a reactivity for polyubiquitinated proteins while usually lacking substantial proteasome reactivity and showing, in addition, p62 protein. The gene discussed is SQSTM1; the disease is neurodegenerative disease.