The population (82 mice) was classified for tumor size in two groups on the basis of the median weight of tumors (3.55 g): big tumors (above median) and small tumors (below median), each composed of 41 mice; it was then classified by expression of JAM-A (31 JAM-A −/− mice and 51 JAM-A +/+ mice) and by incidence of metastasis (55 mice did not develop metastasis and 27 did). This evidence concerns the gene F11R and neoplasm.