Of interest, we have recently shown that miR-183, one of the miRNAs that is highly expressed in both colon adenomas and carcinomas, negatively regulated EGR1 expression, which in turn affects the expression of PTEN. Further, miR-183 is implicated in tumor cell migration by the negative regulation of both EGR1 and PTEN[47]. The gene discussed is PTEN; the disease is carcinoma.