HIPK3 and cancer: In hepatocellular carcinoma Huh-7 cells, BCL-X is alternatively spliced into anti-apoptotic large RNA isoform, BCL-XL, more than pro-apoptotic small RNA isoform, BCL-XS[15]; HIPK3 is spliced into exon 11-excluded U (-) as well as exon 11-included U (+) isoforms for interaction with Fas/FADD to modulate apoptosis in the developmental process [16]; and RON/MISTR1 is spliced into 5-kb full-length (flRON) RNA and 2-kb exon 11-excluded RON (sfRON) RNA isoforms, the latter of which has been correlated with epithelial to mesenchymal transition in cancer cell invasion and metastasis [17], [18].