Interestingly, our results showed that the ALDH+/CD133+ subpopulations of SW480, HCT-116, DLD-1, and HT29 (Figure 1B) colorectal cancer cells expressed higher levels of STAT3 phosphorylation (Y705) compared with the ALDH−/CD133− subpopulation cells. This evidence concerns the gene LDHA and colorectal cancer.