STAT3 and cancer: The inhibition of STAT3 by GO-Y030 also downregulated the expression of many known STAT3-regulated genes in colorectal cancer stem cells related to cancer cell proliferation, survival, and angiogenesis, such as Cyclin D1 (Bromberg et al, 1999), survivin (Gritsko et al, 2006), Bcl-2, and Bcl-XL (Bromberg et al, 1999; Figure 2C).