We observed that GO-Y030 inhibited STAT3 phosphorylation (Y705), but not ERK1/2 phosphorylation (T202/Y204) in the ALDH+/CD133+ subpopulation of SW480, HCT-116, DLD-1, and HT29 (Figure 2A) colorectal cancer cell lines. Here, MAPK3 is linked to colorectal cancer.