PLCE1 and esophageal squamous cell carcinoma: Most recently, for the first time, Wang et al. found that rs2274223, a nonsynonymous SNP of the PLCE1 gene, was associated with an increased risk of ESCC and GCA in a Chinese population by a two-stage GWAS in 9,053 ESCC cases, 2,766 GCA cases and 11,013 controls [8].