In the present study, we performed genotyping analyses of three potentially functional SNPs in PLCE1 (rs2274223A/G, rs3203713A/G and rs11599672T/G) in non-Hispanic whites and assessed their associations with risk of SCCHN in our ongoing hospital-based case-control study of 1,098 SCCHN cases and 1,090 cancer-free controls matched to cases on age (± 5 years) and sex. Here, PLCE1 is linked to head and neck squamous cell carcinoma.