PLCE1 and head and neck squamous cell carcinoma: Despite the present study with 1,098 SCCHN cases and 1,090 controls may have a limited power to detect weak associations between polymorphisms of PLCE1 including rs2274223 and overall risk of SCCHN compared with the published GWA studies [9,10], our results did show that subjects carrying more risk alleles in PLCE1 (rs2274223G, rs3203713G and rs11599672T) had a higher risk of SCCHN than those with zero to one risk allele, especially for SCCHN arising at non-oropharyngeal sites, suggesting a joint effect of these SNPs on susceptibility to SCCHN.