We first conducted in vitro experiments of a new candidate regulator of E-cadherin listed in Table 1, KLF5, to investigate whether KLF5 affects E-cadherin expression and induces morphologic changes characteristic of EMT using A549 lung adenocarcinoma cell line, which is well known to exhibit EMT in response to TGF-[64]. This evidence concerns the gene CDH1 and lung adenocarcinoma.