BAFF ligation to B-ALL cells also triggered the activation of MAPK signaling, with the phosphorylation of ERK1/2 and JNK/SAPK kinases (Figure 5B), as well as PI3K/Akt signaling, with phosphorylation of Akt (Figure 5C). This evidence concerns the gene TNFSF13B and acute lymphoblastic leukemia.