BAFF ligation triggered NF-κB signaling in leukemia B-cells, as shown by the phosphorylation of the catalytic subunits IKKα/IKKβ, the inhibitory protein IKBα, and the transcription factor p105/NF-κB1 (Figure 5A), and subsequent augmentation of p50. The gene discussed is CHUK; the disease is leukemia.