A recent study reported the expression of BAFF-R in B-ALL cells and showed that BAFF stimulation supported the survival of leukemia cells, attenuating the cytotoxic effects of the kinase inhibitor nilotinib in Ph-positive leukemias.[42] Our work on a larger dataset of patients shows that in addition to functional BAFF-R, B-ALL cells also express TACI and BCMA, and that virtually all patients express at least one of the BAFF-system receptors. The gene discussed is TNFRSF17; the disease is acute lymphoblastic leukemia.