Using a soluble BCMA-Fc fusion protein with high-affinity for BAFF and APRIL, preventing their ligation to their cognate receptors on target cells,[41] we observed that BCMA-Fc inhibits or abrogates the survival effects of BAFF in leukemia B-ALL cells (Figure S2). The gene discussed is TNFRSF17; the disease is acute lymphoblastic leukemia.