Therefore, NRXN1 may influence frontal white matter in schizophrenia and ASD through disrupted interaction with its glutamatergically-related binding partners, or possibly via direct glutamatergic involvement as the NRXN1 knock out mouse demonstrates decreased excitatory synaptic strength and decreased prepulse inhibition [72]. The gene discussed is NRXN1; the disease is schizophrenia.