LEP and obesity due to melanocortin 4 receptor deficiency: During obesity, there is a higher content of superoxide radicals and nitrotyrosine in the coronary endothelium, and early obesity is characterized by increased OS and endothelial dysfunction associated with increased leptin levels [52]: in addition, it has been reported that weight loss improves endothelium-dependent vasodilatation, improves endothelial activation markers, and decreases proinflammatory cytokine levels [50].