Pro-apoptotic agents 'Oblimersen', an antisense inhibitor of Bcl-2, and 'Sorafenib', an orally active small molecule inhibitor of wild type and mutant BRAF or PLX4032 a potent inhibitor of BRAF with the V600E mutation are at the forefront of novel therapies developed for advanced metastatic disease [19,20]. This evidence concerns the gene BRAF and metastatic neoplasm.