The most significant network from the Imd2/Imd0 comparison is "Hematological Disease, Small Molecule Biochemistry, Cellular Compromise" (Additional file 2 Table S3); further pathway analysis of this subset (data not shown) showed the most significant pathways within this network were the "Complement System", "Granzyme B signalling" (i.e. Granzyme B pathway), "Huntington's Disease signalling" and "NRF2-mediated oxidative stress response"; the latter two pathways predominantly involve heat shock proteins. This evidence concerns the gene GZMB and hematologic disorder.