Thus, we inferred that, except for the various effect of single LPS on the development of SLE and LN, together with the synergic effect of IFN-λ1 and LPS on the chemokines secretion, they could play a powerful effect on the inflammation process of SLE, and promote the disease aggravation in patients with SLE, especially with LN. The gene discussed is IFNL1; the disease is systemic lupus erythematosus.