We next chose to study the dose-response curves for IFN-λ1 inducing IP-10, MIG and IL-8, demonstrating that in SLE patients, both 10 ng/ml and 50 ng/ml IFN-λ1 had effects on the secretion of IP-10 (P = 0.033, 0.005, Figure 5d) and stimulated more IP-10 than normal controls (P = 0.024, 0.047, Figure 5d). This evidence concerns the gene IFNL1 and systemic lupus erythematosus.