The most widely studied members ABCB1 (MDR1/P-glycoprotein), ABCC1 (multidrug resistance protein, MRP1) and ABCG2 (breast cancer resistance protein, BCRP) have the ability to export a wide variety of structurally unrelated chemotherapeutic compounds from cancer cells, thereby conferring MDR to these cell [33]. The gene discussed is ABCB1; the disease is cancer.