INS and type 2 diabetes mellitus: The findings of this study are consistent with those of the Orals Plus Apidra and LANTUS (OPAL) study [5] in which one injection of insulin glulisine added to insulin glargine plus OHAs significantly improved HbA1c levels in people with T2DM, irrespective of whether the prandial insulin was administered at breakfast or at the main meal.