For example, it delays disease onset and extends the survival in the amyotrophic lateral sclerosis transgenic mouse model [27], it rescues renal hypoplasia in paired box 2 (Pax2)-deficient mice [28] and promotes cochlear hair cell survival in the Pou4f3 mouse model of deafness [29]. The gene discussed is PAX2; the disease is amyotrophic lateral sclerosis.