IFNB1 and viral infectious disease: While it is possible that CHX treatment prevents the synthesis of an inducible E3 ligase that targets IRF3 for degradation, we propose that one or more proteosome-independent proteases that target IRF3 are induced by virus, leading to the termination of IFNβ transcription (a model of IRF3 inactivation during acute virus infection is shown in Fig. S13).