While it is possible that CHX treatment prevents the synthesis of an inducible E3 ligase that targets IRF3 for degradation, we propose that one or more proteosome-independent proteases that target IRF3 are induced by virus, leading to the termination of IFNβ transcription (a model of IRF3 inactivation during acute virus infection is shown in Fig. S13). The gene discussed is IRF3; the disease is viral infectious disease.