Atherogenic index (AI), i.e. the ratio of ApoB to ApoA-I, is found to track closely during the first year of life.5 Abnormal lipoprotein profiles in childhood persist into adult life and elevated Apo B levels in young adults have been linked to atherosclerosis in later life.5 Young age can be viewed as an opportunity to begin preventive interventions to change risk factors for cardio-vascular risk. The gene discussed is APOB; the disease is atherosclerosis.