Interestingly, STAT5B, HNF4 and HNF6 play important roles in liver function [34-36] which do not feature in typical clinical descriptions of ATR-X syndrome yet raises the question of whether ATRX, which appears to be quite highly expressed in the fetal liver [31], has a role in liver development and/or function which is not clinically obvious in ATR-X syndrome. The gene discussed is STAT5B; the disease is Alpha-thalassemia - X-linked intellectual disability syndrome.