On regression analyses, changes in BMI predicted changes in insulin (B = 4.9 ± 2, p = 0.03), insulin resistance (B = 1.75 ± 0.65, p = 0.02) and leptin (B = 2.2 ± 1, p = 0.046) but not on ghrelin (B = 38 ± 72, p = 0.61), adiponectin (B = -0.02 ± 1, p = 0.98) or resistin (B = -0.09 ± 0.25, p = 0.74). This evidence concerns the gene LEP and Insulin resistance.