In the Inter99 population, the major G-allele of rs2605100 in LYPLAL1 associated with fasting serum triglyceride concentrations (per allele effect(β) = 3%, ((95% confidence interval(CI))1;5), padditive (add) = 2.7×10−3), fasting serum insulin concentrations (β = 3% (1;5), padd = 2.5×10−3), and homeostasis model assessment-insulin resistance (HOMA-IR) (β = 4% (1;6), padd = 1.5×10−3) (table 1). The gene discussed is LYPLAL1; the disease is Insulin resistance.