The minor G-allele of rs10146997 in NRXN3 associated with increased WC among women (β = 0.55cm (0.20;0.89), padditive = 1.7×10−3, pinteraction = 1.0×10−3), but showed no associations with obesity related metabolic traits. Here, NRXN3 is linked to obesity due to melanocortin 4 receptor deficiency.