These studies have either indirectly inferred roles for NKT cells[10], [12], [14], altered the activity/numbers of NKT cells in pre-existing obesity models[11], [13], [15], [16], [25], or have deleted other cell types i.e. CD8+ T-cells, in addition to NKT cells[13], that have been implicated in mediating increased inflammation and metabolic dysregulation in obesity. Here, CD8A is linked to obesity due to melanocortin 4 receptor deficiency.