After stratified by APOE e4 genotype, SNP2 still significantly associated with AD among non-APOE e4 carriers after controlling for FDR (AOR  = 0.38, 95% CI  = 0.18–0.82, Table 4), and only NINJ2 SNP4 was significantly associated with AD risk among APOE e4 carriers under additive model (AOR  = 3.03, 95% CI  = 1.07–8.61, Table 4). Here, APOE is linked to Alzheimer disease.