In the model adjusted for age, sex, survey and cardiometabolic risk factors (model 2), IL-18, adiponectin, sE-selectin and sICAM-1 were each significantly associated with incident type 2 diabetes with HRs betwen 1.11 and 1.67 (0.33 for the protective adipokine adiponectin). This evidence concerns the gene IL18 and type 2 diabetes mellitus.