NFATC1 and exocrine pancreatic carcinoma: Using human-derived pancreatic carcinoma cell lines, they demonstrated that the nuclear localization of transcriptionally active NFATc1 is a calcineurin-dependent process that was inhibited by cyclosporine A. Treatment with cyclosporine A also inhibited in vitro cell cycle progression and anchorage-independent proliferation of the Panc1 cell line [26].