To further explore the effects of NF-κB activation, we examined the expression levels of certain NF-κB target genes including COX-2, cyclin D1, MMP-9, MMP-2, Bcl-2, c-myc, and survivin by real-time RT-PCR and western blotting, respectively, using the tumor tissues obtained from the compound KCI transgenic animals. The gene discussed is MMP9; the disease is neoplasm.