[7], [8], [9], [10], [11], [12], [13] In contrast, down-regulation of the gene is associated with the progression of chronic liver disease.[14] More recent work has also revealed that overexpressing BI-1 not only transforms NIH3T3 cells but also enhances cancer metastasis by altering glucose metabolism and activating the sodium-hydrogen exchanger. [13], [15] Finally, two groups have shown that overexpression of the protein protects animals from obesity-associated insulin resistance [16] and stroke and traumatic brain injury. [17]. Here, TMBIM6 is linked to cancer.