The activation of Notch-signaling induces expression of its membrane-bound ligands known as Delta-1 like 1, 3, 4 and Jagged-1, 2, and then, these expressed ligands stimulate Notch receptor expressed on the surface of other cells by cell-to-cell contact [17], [18].This activation loop of Notch-signaling may have some advantages for the effective replication of HCV through the activation of cell proliferation of HCV-infected cells, and lead to constitutive activation of Notch during the course of tumor development. The gene discussed is JAG1; the disease is neoplasm.