PLA2G5 and respiratory failure: Unexpectedly, in contrast to Pla2g5-Tg neonates that exhibited fatal respiratory failure (see above), systemic Pla2g10-Tg mice displayed no apparent abnormality of the respiratory tract with normal alveolar architecture and surfactant composition [8], despite the fact that sPLA2-X can potently hydrolyze surfactant PC in vitro [18].