Thus, an adipose tissue-specific, Bcmo1-dependent production of retinoids, such as retinoic acid, from BC might explain the down-regulation of iWAT PPARγ expression levels and the overall changes in iWAT gene expression patterns and adiposity-related end-points observed in this work in WT mice following chronic exposure to a BC-enriched diet. The gene discussed is PPARG; the disease is breast cancer.