CYP26A1 and breast cancer: In contrast, iWAT mRNA levels of CYP26a1, a retinoic acid hydroxylase that is transcriptionally induced by retinoic acid in a strictly RAR-dependent manner [36]; [37], were increased by 138% after BC supplementation in the WT mice, but not in the Bcmo1-/- mice (Figure 5E), suggesting a Bcmo1-dependent enhancement of retinoic acid signalling in iWAT following chronic BC supplementation.