Moreover, we and others were able to determine Bone Morphogenetic Protein 4 (BMP4), BMP7 and TGFβ as important modulators of melanoma initiation and progression (Poser et al, 2005; Rothhammer et al, 2005, 2007; Javelaud et al, 2008). This evidence concerns the gene TGFB1 and melanoma.