Hoek et al (2004) studied the expression profiles of melanocytes compared with invasive melanoma cells by microarray analysis. They revealed that expression of CTGF is upregulated in advanced stages of melanoma progression compared with melanocytes, which is in line with our studies. The impact of CTGF on migratory potential was also observed in other tumour types, for example, in glioblastoma multiforme cells, where an overexpression of CTGF led to an increased migratory potential (Yin et al, 2010). This evidence concerns the gene CCN2 and glioblastoma.