High c-Met expression (HR:3.50, 95% CI:1.56–7.85), macroscopic type (HR:4.78, 95% CI:1.69–13.4), intrahepatic metastasis (HR:2.78, 95% CI:1.60–4.82), lymph node metastasis (HR:2.94, 95% CI:1.70–5.08), venous invasion (HR:4.62, 95% CI:1.13–18.8), and EGFR overexpression (HR:1.98, 95% CI:1.12–3.51) were significant predictors of disease-free survival (Table 3). The gene discussed is EGFR; the disease is metastatic malignant neoplasm in the lymph nodes.