The combination of the two high-risk genotypes 2*2/1*2 of ALDH 2 and TT/TC of MTHFR C677T resulted in a 4-fold higher risk of developing BCH, a 3.7-fold increased risk of ESCD, and a 8.72 times higher ESSC risk. The gene discussed is MTHFR; the disease is choreatic disease.