Consistent with our findings in the basal-breast cancer cell line, AU565 cells (subgroup 7) demonstrated that silencing of HIF1A (HIF-1α), but not EPAS1 (HIF-2α), led to the abolishment of the exaggerated hypoxia response seen in these cells (Figure 7D and Additional file 4, Figure S18). The gene discussed is EPAS1; the disease is breast cancer.