EPAS1 and central nervous system cancer: Our findings which demonstrate that elevated expression of HIF-1α mRNA in the basal and HER2 related breast tumors with basal-like features, including subgroup 7 tumors, correlates with hypoxia response are consistent with recent studies reporting higher mRNA levels of HIF-1α and EPAS1 (HIF-2α) in glioma stem cells and renal epithelial cells [24,25].