In mice where the endogenous Sox10 locus has been replaced by a LacZ cassette, Erbb3 expression is initiated in premigratory NC but is lost once the cells begin migrating [10], suggesting Erbb3 regulation by Sox10. Furthermore Erbb3 transcript levels increase upon overexpression of Sox10 in Neuro2A neuroblastoma cells [10]. This evidence concerns the gene SOX10 and neuroblastoma.