We recently showed that, although it does not directly mediate cell migration, CXCR7 can regulate TEM of CXCR4+CXCR7+ tumor cells towards CXCL12, an effect that can be blocked by CXCR7-specific antagonists and the second CXCR7 chemokine ligand, CXCL11 [30]. This evidence concerns the gene CXCR4 and neoplasm.