NHERF1 and carcinoma: A similar phenomenon has been noted in colorectal cancer, where membranous EBP50 loss and increased cytoplasmic expression has been noted in the colorectal adenoma-to-carcinoma transition, with subsequent increases in cellular invasion and epithelial-to-mesenchymal transition, processes that demonstrated reversibility when EBP50 was reexpressed at the apical membrane of intestinal epithelium[13].