KLK3 and cancer: Despite this, in the era of prostate specific antigen (PSA) screening, researchers have now estimated that clinically insignificant prostate cancer is actually overdiagnosed at a rate of 29% for whites and 44% for blacks, the PSA screen resulting in the detection of cancers that otherwise would only have been detected during autopsy in up to 15% and 37% of tumors in whites and blacks, respectively[2].