SAT2 and Stroke: For example, in two well-regarded studies, risk of stroke is associated with either global hypomethylation, as assessed by LINE-1 bisulfite pyrosequencing (Baccarelli et al. 2010), or global hypermethylation, as assessed using MethyLight at ALU and SAT2 (spermidine/spermine N1-acetyltransferase family member 2) (Kim M et al. 2010).