The therapeutic approach to metastatic colorectal cancer (mCRC) patients has progressively changed in the last few years, thanks to the introduction of biologic drugs in the daily practice, such as cetuximab, a monoclonal antibody (MoAb) directed against the epidermal growth factor receptor (EGFR), and bevacizumab, a MoAb that blocks the vascular endothelial growth factor (VEGF) [1]. Here, EGFR is linked to metastatic colorectal cancer.