CDK4 and urinary bladder cancer: For example MGHU1 human bladder cancer and G361 human melanoma cells both exhibited total cell death with the same dose of 200 μM THR53 but respectively had markedly different endogenous Cdk4 values of 3.605 ± 0.735 and 6.035 ± 1.765 and Cyclin D1 values of 3.465 ± 0.832 and 1.055 ± 0.292 [24].