Habjan et al. reported that wt RVFV NSs also induced PKR degradation and demonstrated that an RVFV C13 strain carrying biologically inactive NSs induced fatal hepatic disease in C57BL/6 mice lacking PKR [127]; these mice are competent for inducing type-I IFNs in response to viral RNA replication or poly (I):poly (C) [128]. The gene discussed is EIF2AK2; the disease is liver disorder.