In addition to TP53 mutations [14], squamous cell lung carcinomas have been shown to harbor amplifications of PIK3CA[15], SOX2[16], and EGFR[16] as well as EGFR variant III mutations [17]DDR2 mutations [18] and rare amplifications of PDGFRA/KIT[19], [20] and BRF2[21]. This evidence concerns the gene EGFR and squamous cell lung carcinoma.