FGFR1 and non-small cell lung carcinoma: In contrast, three out of five shRNA constructs targeting FGFR1, all of which led to a 3- to 5-fold decrease in FGFR1 protein levels relative to shRNA controls (Figure 2a), significantly inhibited cell survival in an NSCLC cell line carrying a focal FGFR1 amplification (NCI-H1581; Figure 2b).