Among the 49 G6PD A- individuals, 1/24 treated with AL and 3/24 treated with CD developed severe anaemia; among hemizygous boys, 2/9 in CD group and 1/7 in the AL group developed severe anaemia; 5/9 in the CD group had a fall in haemoglobin of 2 g/dL or more by day 3, compared to 1/6 in the AL group (Table 2). This evidence concerns the gene G6PD and anemia.