Macrophages are known to cause early glomerular injury in STZ-induced diabetes and also to be involved in the mechanisms that cause progressive glomerular and tubular damage [5,10,42,43]; in addition, ICAM-1 and MCP-1 are considered as a central molecule involved in macrophage influx in DN [9,11,44-46]. The gene discussed is ICAM1; the disease is diabetes mellitus.