TGFB1 and Glomerular sclerosis: Ang II hemodynamically could significantly increase blood pressure, glomerular capillary pressure, and the permeability of filtration membrane, which promoted glomerular sclerosis and renal interstitial fibrosis.13 It also had non-hemodynamic effects, like increasing the expression of TGF-β, chemokines, and the activity of macrophage.