BRAF and hyperplastic polyposis syndrome: The presence of “mixed polyps,” as they were previously known (now called SSA/P with dysplasia), which demonstrate a very high rate of somatic BRAF mutation (80–90%) [76] and therefore, by implication, origin in a serrated polyp, provides a plausible precursor lesion for the CRC which arises in serrated polyposis [6, 19, 50, 56, 57].