Mutations in CACNA1C, which encodes the alpha 1C subunit of the voltage-dependent, L-type calcium channel, lead to lack of voltage-dependent inactivation and prolonged inward calcium current and cause Timothy syndrome (LQT8), a multisystem disorder characterized by long QT intervals and cardiac, hand/foot, facial, and neurodevelopmental features; malignant VT is present in 80% and are the leading cause of death [32]. The gene discussed is CACNA1C; the disease is Timothy syndrome.