CSMD2 and Schnyder corneal dystrophy: We also replicated an association with SCA risk for SNP rs1325258 in the CSMD2 gene (adjusted OR = 2.27, 95% CI:1.681, 2.859, p = 0.0061), one of 6 genes meeting significance threshold of p < 10-4 (but not genome-wide significance) in Oregon-SUDS GWAS on SCD but not validated in ARIC/CHS [33].