NOS3 and autosomal dominant cerebellar ataxia: Although many of the 160 genes represented in the top 300 SNP associations are poorly explored vis a vis cardiovascular biology, it is noteworthy that one-quarter (n = 41) of these loci are genes with evidence of a role in cardiovascular phenotypes, 2 of which are candidate genes with high suspicion for influencing SCA risk, CACNA1C(LQT8) and NOS3 [31,32].