Although we did not test our SNP associations in a validation cohort, we found associations in genes with high prior likelihood of mediating SCA risk in the setting of CAD (ESR1, CACNA1C, NOS3) and our replication of associations with SCA risk for genetic variation in 3 previously reported genes (NOS1AP, CSMD2, AGTR1) substantiates the value of this study. This evidence concerns the gene AGTR1 and autosomal dominant cerebellar ataxia.